Publications
Full list at Google Scholar
2026
DoAtlas-2: A Foundation for Self-Evolving Causal Biomedical Discovery
Yulong Li, Rong Xia, Yuxuan Zhang, Jianxu Chen, Xiwei Liu, Haochen Xue, Maosheng Li, Yuhang Liu, Yibo Yuan, Yutong Xie, Chong Li, Jionglong Su, Hagai Rossman, Eran Segal, Imran Razzak. (2026). DoAtlas-2: A Foundation for Self-Evolving Causal Biomedical Discovery. arXiv, preprint. DOI Preprint
PhenoBench: Mapping What a Deeply Phenotyped Human Cohort Can Tell Us
Gal Sapir, Alon Diament, Adva Wolf, Doron Yaya-Stupp, Dikla Gelbard Solodkin, Dana Azouri, Anat Etzion-Fuchs, Guy Lutsker, Eran Segal, Hagai Rossman✉. (2026). PhenoBench: Mapping What a Deeply Phenotyped Human Cohort Can Tell Us. arXiv, preprint. DOI Preprint Accepted for oral presentation at the AIDaR Workshop at NeurIPS 2026, Paris, France, 12 December 2026. OpenReview.
Grounding Health AI: Architecture and Evaluation of a Domain-Expert Metabolic Health Agent
Alon Diament, Gal Sapir, Maria Gorodetski, Adva Wolf, Anna Rice, Dana Azouri, Anat Etzion-Fuchs, Dikla Gelbard Solodkin, Yeela Talmor-Barkan, Guy Lutsker, Eran Segal, Hagai Rossman✉. (2026). Grounding Health AI: Architecture and Evaluation of a Domain-Expert Metabolic Health Agent. medRxiv, preprint. DOI Preprint
Sarah Kohn, Guy Lutsker, Alon Diament, Smadar Shilo, Adam Gabet, Gil Sasson, Gili Wolf, Adva Wolf, Anastasia Godneva, Adina Weinberger, Hagai Rossman✉, Eran Segal✉. (2026). A foundation model of wearable pulse oximetry reveals physiological signatures of health and cardiometabolic risk. medRxiv, preprint. DOI Preprint
Pre-activity glycemic prediction prioritizes post-meal movement
Smadar Shilo, Gal Sapir, Guy Lutsker, Yeela Talmor-Barkan, Anastasia Godneva, Alon Diament, Marcos Matabuena, Eran Segal, Hagai Rossman. (2026). Pre-activity glycemic prediction prioritizes post-meal movement. medRxiv, preprint. DOI Preprint
Yeela Talmor-Barkan, Ran Kornowski, Guy Witberg, Keren Skalsky, Iris Kalka, Hagai Rossman, Eran Segal, Nancy Yacovzada. (2026). Long-term comparative efficacy and safety of direct oral anticoagulants versus warfarin in patients with atrial fibrillation and chronic kidney disease: A nationwide observational study. Heart Rhythm. DOI Paper
A Deep Learning-Based Predictive Algorithm for Metabolic Syndrome Detection in the U.S. Population
Cristina Correa, Ruben Solozabal, Ziad Akram Ali Hammouri, Fernando Gómez-Peralta, Hagai Rossman, Juan C. Vidal, David C. Klonoff, Eran Segal, Marcos Matabuena. (2026). A Deep Learning-Based Predictive Algorithm for Metabolic Syndrome Detection in the U.S. Population. medRxiv, preprint. DOI Preprint
Smadar Shilo, Yeela Talmor-Barkan, Maria Gorodetski, Dana Azouri, Anastasia Godneva, Eran Segal, Hagai Rossman. (2026). Heterogeneity of Insulin Resistance Surrogates in Thousands of Non-Diabetic Adults: Multi-Modal Data Reveals Discordant Metabolic Phenotypes. medRxiv, preprint. DOI Preprint Code
Simulating clinical interventions with a generative multimodal model of human physiology
Guy Lutsker, Gal Sapir, Jordi Merino, Smadar Shilo, Anastasia Godneva, Eli Meirom, Shie Mannor, Hagai Rossman, Gal Chechik, Eran Segal✉. (2026). Simulating clinical interventions with a generative multimodal model of human physiology. arXiv, preprint. DOI Preprint
Tomer Segev, Daniel Barak, Liron Zahavi, Anastasia Godneva, Michal Rein, David Krongauz, Dorit Samocha-Bonet, Hagai Rossman, Adina Weinberger, Eran Segal✉. (2026). Diet–microbiome associations in 10,068 individuals from the Human Phenotype Project to guide personalized nutrition. Nature Medicine, 32(5): 1884-1894. DOI Paper Preprint Code
Impact of daily diet on sleep quality
Mariya Shkolnik, Gal Sapir, Smadar Shilo, Yeela Talmor-Barkan, Eran Segal✉, Hagai Rossman✉. (2026). Impact of daily diet on sleep quality. Nature Health. DOI Preprint Code Paper
A foundation model for continuous glucose monitoring data
Guy Lutsker, Gal Sapir, Smadar Shilo, Jordi Merino, Anastasia Godneva, Jerry R. Greenfield, Dorit Samocha-Bonet, Raja Dhir, Francisco Gude, Shie Mannor, Eli Meirom, Eric P. Xing, Gal Chechik, Hagai Rossman✉, Eran Segal✉. (2026). A foundation model for continuous glucose monitoring data. Nature, 650(8103): 978-986. DOI Paper Code
Yeela Talmor-Barkan, Michal Shapira, Smadar Shilo, Maria Gorodetski, Dana Azouri, Yaron Aviv, Yotam Reisner, Anastasia Godneva, Adina Weinberger, Alon Skaat, Anat Loewenstein, Eran Berkowitz, Ran Kornowski, Eran Segal, Hagai Rossman. (2026). RetiMap: Automated Retinal Vascular Measures Link Microvascular Structure to Metabolic Health and Predict Cardiovascular Risk. JACC: Basic to Translational Science, 11(7): 101596. DOI Preprint Paper
2025
Phenome-wide associations of sleep characteristics in the Human Phenotype Project
Sarah Kohn, Alon Diament, Anastasia Godneva, Raja Dhir, Adina Weinberger, Yotam Reisner, Hagai Rossman, Eran Segal✉. (2025). Phenome-wide associations of sleep characteristics in the Human Phenotype Project. Nature Medicine, 31(3): 1026-1037. DOI Paper
Mattia Carletti, Jay Pandit, Matteo Gadaleta, Danielle Chiang, Felipe Delgado, Katie Quartuccio, Brianna Fernandez, Juan Antonio Raygoza Garay, Ali Torkamani, Riccardo Miotto, Hagai Rossman, Benjamin Berk, Katie Baca-Motes, Vik Kheterpal, Eran Segal, Eric J. Topol, Edward Ramos✉, Giorgio Quer✉. (2025). Multimodal AI correlates of glucose spikes in people with normal glucose regulation, pre-diabetes and type 2 diabetes. Nature Medicine, 31(9): 3121-3127. DOI Paper
Sarah Kohn, Alon Diament, Anastasia Godneva, Raja Dhir, Adina Weinberger, Yotam Reisner, Hagai Rossman, Eran Segal. (2025). 0054 The Human Phenotype Project: Metabolomic Signatures of Sleep Characteristics Reveal Gender-Specific Insights. SLEEP, 48(Supplement_1): A24-A25, conference abstract. DOI
Delta ECG: A Genetic Perspective
Zachary Levine, Hagai Rossman, Eran Segal. (2025). Delta ECG: A Genetic Perspective. ICLR 2025 Learning Meaningful Representations of Life Workshop. Openreview
Deep phenotyping of health–disease continuum in the Human Phenotype Project
Lee Reicher†, Smadar Shilo†, Anastasia Godneva, Guy Lutsker, Liron Zahavi, Saar Shoer, David Krongauz, Michal Rein, Sarah Kohn, Tomer Segev, Yishay Schlesinger, Daniel Barak, Zachary Levine, Ayya Keshet, Rotem Shaulitch, Maya Lotan-Pompan, Matan Elkan, Yeela Talmor-Barkan, Yaron Aviv, Maya Dadiani, Yonatan Tsodyks, Einav Nili Gal-Yam, Haim Leibovitzh, Lael Werner, Roie Tzadok, Nitsan Maharshak, Shin Koga, Yulia Glick-Gorman, Chani Stossel, Maria Raitses-Gurevich, Talia Golan, Raja Dhir, Yotam Reisner, Adina Weinberger, Hagai Rossman, Le Song, Eric P. Xing✉, Eran Segal✉. (2025). Deep phenotyping of health–disease continuum in the Human Phenotype Project. Nature Medicine, 31(9): 3191-3203. DOI Paper
CardioPRIME: Cardiovascular Physiological Representation Integration With Multimodal Embeddings
Zachary Levine, Hagai Rossman, Eran Segal. (2025). CardioPRIME: Cardiovascular Physiological Representation Integration With Multimodal Embeddings. LMRL Workshop at ICLR 2025. Paper
2024
Zachary Levine, Iris Kalka, Dmitry Kolobkov, Hagai Rossman, Anastasia Godneva, Smadar Shilo, Ayya Keshet, Daphna Weissglas-Volkov, Tal Shor, Alon Diament, Yeela Talmor-Barkan, Yaron Aviv, Tom Sharon, Adina Weinberger, Eran Segal. (2024). Genome-wide association studies and polygenic risk score phenome-wide association studies across complex phenotypes in the human phenotype project. Med, 5(1): 90-101.e4. DOI
Continuous glucose monitoring and intrapersonal variability in fasting glucose
Smadar Shilo, Ayya Keshet, Hagai Rossman, Anastasia Godneva, Yeela Talmor-Barkan, Yaron Aviv, Eran Segal✉. (2024). Continuous glucose monitoring and intrapersonal variability in fasting glucose. Nature Medicine, 30(5): 1424-1431. DOI Paper
Guy Lutsker, Hagai Rossman, Nastya Godneva, Eran Segal. (2024). COMPRER: A Multimodal Multi-Objective Pretraining Framework for Enhanced Medical Image Representation. medRxiv preprint, preprint. DOI Paper
Genetic underpinnings of predicted changes in cardiovascular function using self supervised learning
Zachary Levine, Guy Lutsker, Anastasia Godneva, Adina Weinberger, Maya Pompan, Yeela Talmor-Barkan, Yotam Reisner, Hagai Rossman, Eran Segal. (2024). Genetic underpinnings of predicted changes in cardiovascular function using self supervised learning. bioRxiv, preprint. DOI Preprint Related workshop contribution: Delta ECG: A Genetic Perspective (2025), listed separately.
2023
Yeela Talmor-Barkan, Nancy-Sarah Yacovzada, Hagai Rossman, Guy Witberg, Iris Kalka, Ran Kornowski, Eran Segal. (2023). Head-to-head efficacy and safety of rivaroxaban, apixaban, and dabigatran in an observational nationwide targeted trial. European Heart Journal - Cardiovascular Pharmacotherapy, 9(1): 26-37. DOI Paper
CGMap: Characterizing continuous glucose monitor data in thousands of non-diabetic individuals
Ayya Keshet, Smadar Shilo, Anastasia Godneva, Yeela Talmor-Barkan, Yaron Aviv, Eran Segal✉, Hagai Rossman✉. (2023). CGMap: Characterizing continuous glucose monitor data in thousands of non-diabetic individuals. Cell Metabolism, 35(5): 758-769.e3. DOI
A Multimodal Dataset of 21,412 Recorded Nights for Sleep and Respiratory Research
Alon Diament, Maria Gorodetski, Adam Jankelow, Ayya Keshet, Tal Shor, Daphna Weissglas-Volkov, Hagai Rossman, Eran Segal. (2023). A Multimodal Dataset of 21,412 Recorded Nights for Sleep and Respiratory Research. NeurIPS ML4H Workshop. Paper
2022
The role of models in the covid-19 pandemic
David M. Steinberg, Ran D. Balicer, Yoav Benjamini, Hilla De-Leon, Doron Gazit, Hagai Rossman, Eli Sprecher. (2022). The role of models in the covid-19 pandemic. Israel Journal of Health Policy Research, 11(1): 36. DOI Paper
PyMSM: Python package for Competing Risks and Multi-State models for Survival Data
Hagai Rossman, Ayya Keshet, Malka Gorfine✉. (2022). PyMSM: Python package for Competing Risks and Multi-State models for Survival Data. Journal of Open Source Software, 7(78): 4566. DOI Paper Code
Estimating the effect of cesarean delivery on long-term childhood health across two countries
Ayya Keshet†, Hagai Rossman†, Smadar Shilo†, Shiri Barbash-Hazan†, Guy Amit, Maytal Bivas-Benita, Chen Yanover, Irena Girshovitz, Pinchas Akiva, Avi Ben-Haroush, Eran Hadar, Arnon Wiznitzer✉, Eran Segal✉. (2022). Estimating the effect of cesarean delivery on long-term childhood health across two countries. PLOS ONE, 17(10): e0268103. DOI Paper Code
Nowcasting the spread of SARS-CoV-2
Hagai Rossman, Eran Segal✉. (2022). Nowcasting the spread of SARS-CoV-2. Nature Microbiology, 7(1): 16-17. DOI Paper
2021
Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak
Asaf Benjamin, Yael Kuperman, Noa Eren, Ron Rotkopf, Maya Amitai, Hagai Rossman, Smadar Shilo, Tomer Meir, Ayya Keshet, Orit Nuttman-Shwartz, Eran Segal, Alon Chen✉. (2021). Stress-related emotional and behavioural impact following the first COVID-19 outbreak peak. Molecular Psychiatry, 26(11): 6149-6158. DOI Paper
Signals of hope: gauging the impact of a rapid national vaccination campaign
Smadar Shilo†, Hagai Rossman†, Eran Segal✉. (2021). Signals of hope: gauging the impact of a rapid national vaccination campaign. Nature Reviews Immunology, 21(4): 198-199. DOI Paper
Prediction of Childhood Obesity from Nationwide Health Records
Hagai Rossman, Smadar Shilo, Shiri Barbash-Hazan, Nitzan Shalom Artzi, Eran Hadar, Ran D. Balicer, Becca Feldman, Arnon Wiznitzer, Eran Segal✉. (2021). Prediction of Childhood Obesity from Nationwide Health Records. The Journal of Pediatrics, 233: 132-140.e1. DOI
Hospital load and increased COVID-19 related mortality in Israel
Hagai Rossman†, Tomer Meir†, Jonathan Somer, Smadar Shilo, Rom Gutman, Asaf Ben Arie, Eran Segal✉, Uri Shalit‡✉, Malka Gorfine‡✉. (2021). Hospital load and increased COVID-19 related mortality in Israel. Nature Communications, 12(1): 1904. DOI Paper Code
Iris N. Kalka, Amir Gavrieli, Smadar Shilo, Hagai Rossman, Nitzan Shalom Artzi, Nancy-Sarah Yacovzada, Eran Segal✉. (2021). Estimating heritability of glycaemic response to metformin using nationwide electronic health records and population-sized pedigree. Communications Medicine, 1(1): 55. DOI Paper
10 K: a large‐scale prospective longitudinal study in Israel
Smadar Shilo, Noam Bar, Ayya Keshet, Yeela Talmor-Barkan, Hagai Rossman, Anastasia Godneva, Yaron Aviv, Yochai Edlitz, Lee Reicher, Dmitry Kolobkov, Bat Chen Wolf, Maya Lotan-Pompan, Kohava Levi, Ori Cohen, Hila Saranga, Adina Weinberger, Eran Segal. (2021). 10 K: a large‐scale prospective longitudinal study in Israel. European Journal of Epidemiology, 36(11): 1187-1194. DOI Paper
COVID-19 dynamics after a national immunization program in Israel
Hagai Rossman, Smadar Shilo, Tomer Meir, Malka Gorfine‡✉, Uri Shalit‡✉, Eran Segal‡✉. (2021). COVID-19 dynamics after a national immunization program in Israel. Nature Medicine, 27(6): 1055-1061. DOI Paper
Carole H Sudre, Ayya Keshet, Mark S Graham, Amit D Joshi, Smadar Shilo, Hagai Rossman, Benjamin Murray, Erika Molteni, Kerstin Klaser, Liane D Canas, Michela Antonelli, Long H Nguyen, David A Drew, Marc Modat, Joan Capdevila Pujol, Sajaysurya Ganesh, Jonathan Wolf, Tomer Meir, Andrew T Chan, Claire J Steves, Tim D Spector, John S Brownstein, Eran Segal, Sebastien Ourselin, Christina M Astley. (2021). Anosmia, ageusia, and other COVID-19-like symptoms in association with a positive SARS-CoV-2 test, across six national digital surveillance platforms: an observational study. The Lancet Digital Health, 3(9): e577-e586. DOI
Saar Shoer†, Tal Karady†, Ayya Keshet†, Smadar Shilo†, Hagai Rossman†, Amir Gavrieli, Tomer Meir, Amit Lavon, Dmitry Kolobkov, Iris Kalka, Anastasia Godneva, Ori Cohen, Adam Kariv, Ori Hoch, Mushon Zer-Aviv, Noam Castel, Carole Sudre, Anat Ekka Zohar, Angela Irony, Tim Spector, Benjamin Geiger, Dorit Hizi, Varda Shalev, Ran Balicer, Eran Segal. (2021). A Prediction Model to Prioritize Individuals for a SARS-CoV-2 Test Built from National Symptom Surveys. Med, 2(2): 196-208.e4. DOI
2020
Ayya Keshet†, Amir Gavrieli†, Hagai Rossman†, Smadar Shilo†, Tomer Meir†, Tal Karady, Amit Lavon, Dmitry Kolobkov, Iris Kalka, Saar Shoer, Anastasia Godneva, Ori Cohen, Anat Aka Zohar, Angela Irony, Benjamin Geiger, Yuval Dor, Ran Balicer, Varda Shalev, Eran Segal✉. (2020). The effect of a national lockdown in response to COVID-19 pandemic on the prevalence of clinical symptoms in the population. medRxiv preprint, preprint. DOI Paper
Prediction of gestational diabetes based on nationwide electronic health records
Nitzan Shalom Artzi, Smadar Shilo, Eran Hadar, Hagai Rossman, Shiri Barbash-Hazan, Avi Ben-Haroush, Ran D. Balicer, Becca Feldman, Arnon Wiznitzer✉, Eran Segal✉. (2020). Prediction of gestational diabetes based on nationwide electronic health records. Nature Medicine, 26(1): 71-76. DOI Paper
Longitudinal symptom dynamics of COVID-19 infection
Barak Mizrahi†, Smadar Shilo†, Hagai Rossman†, Nir Kalkstein, Karni Marcus, Yael Barer, Ayya Keshet, Na’ama Shamir-Stein, Varda Shalev, Anat Ekka Zohar, Gabriel Chodick, Eran Segal✉. (2020). Longitudinal symptom dynamics of COVID-19 infection. Nature Communications, 11(1): 6208. DOI Paper
Building an international consortium for tracking coronavirus health status
Eran Segal, Feng Zhang, Xihong Lin, Gary King, Ophir Shalem, Smadar Shilo, William E. Allen, Faisal Alquaddoomi, Han Altae-Tran, Simon Anders, Ran Balicer, Tal Bauman, Ximena Bonilla, Gisel Booman, Andrew T. Chan, Ori Cohen, Silvano Coletti, Natalie Davidson, Yuval Dor, David A. Drew, Olivier Elemento, Georgina Evans, Phil Ewels, Joshua Gale, Amir Gavrieli, Benjamin Geiger, Yonatan H. Grad, Casey S. Greene, Iman Hajirasouliha, Roman Jerala, Andre Kahles, Olli Kallioniemi, Ayya Keshet, Ljupco Kocarev, Gregory Landua, Tomer Meir, Aline Muller, Long H. Nguyen, Matej Oresic, Svetlana Ovchinnikova, Hedi Peterson, Jana Prodanova, Jay Rajagopal, Gunnar Rätsch, Hagai Rossman, Johan Rung, Andrea Sboner, Alexandros Sigaras, Tim Spector, Ron Steinherz, Irene Stevens, Jaak Vilo, Paul Wilmes. (2020). Building an international consortium for tracking coronavirus health status. Nature Medicine, 26(8): 1161-1165. DOI Paper
Axes of a revolution: challenges and promises of big data in healthcare
Smadar Shilo†, Hagai Rossman†, Eran Segal✉. (2020). Axes of a revolution: challenges and promises of big data in healthcare. Nature Medicine, 26(1): 29-38. DOI Paper
Hagai Rossman, Ayya Keshet, Smadar Shilo, Amir Gavrieli, Tal Bauman, Ori Cohen, Esti Shelly, Ran Balicer, Benjamin Geiger, Yuval Dor, Eran Segal✉. (2020). A framework for identifying regional outbreak and spread of COVID-19 from one-minute population-wide surveys. Nature Medicine, 26(5): 634-638. DOI Paper